Transcriptional Feedback in Plant Growth and Defense by PIFs, BZR1, HY5, and MYC Transcription Factors

Abstract Growth of Arabidopsis is controlled by the activity a set bHLH and bZIP transcription factors which phytochrome interacting factor4 ( PIF4) , BRASSINAZOLE-RESISTANT 1 BZR1 ), elongated hypocotyl 5 HY5) have been most extensively studied. Defense responses are MYC MYC2 best characterized. Moreover, hundreds additional proteins (here named co-factors) identified (in)directly may affect expression or these TFs. Thus, regulation genes encoding co-factors becomes an integral part understanding molecular control growth defense. Here, we review RNA-seq data related to PIF, BZR1, HY5, activity, indicate that 125 co-factor affecting PIFs, MYCs themselves under transcriptional TFs, thus revealing potential feedback in The on PIF4 MYCs, mostly results negative . In contrast, for HY5 positive exert balanced regulating photoreceptor-gene expression, whose products directly indirectly PIF4, protein stability as function light. itself both multiple activity. balance between defense through direct cross-regulation previously described, but also MYC2. interlocking feed-forward feed-backward signature robust temporal signaling